2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

Base Information

Chemical Name:2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate
CAS No.:877165-51-0
Molecular Formula:C₂₃H₂₆F₃N₃O₇S₂
Molecular Weight:577.603
Hs Code.:

Synonyms:2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

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Chemical Property of 2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

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Technology Process of 2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

There total 1 articles about 2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 761428-08-4
7-hydroxy-1-methyl-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 877165-51-0
2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 70 ℃; for 24h; Inert atmosphere;

Reference yield: 82.0%

: 877165-51-0
2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

: 159635-49-1
tert-butyl 4-methylidenepiperidine-1-carboxylate

: 4-[2-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 4-methylidenepiperidine-1-carboxylate; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 80 ℃; for 1h; Inert atmosphere;

2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate; With water; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

Reference yield:

: 877165-51-0
2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-yl trifluoro-methanesulphonate

: 159635-49-1
tert-butyl 4-methylidenepiperidine-1-carboxylate

: 877165-81-6
1-methyl-7-piperidin-4-ylmethyl-1H-indole-2-carboxylic acid(5-tert-butyl-3-methanesulphonyl-amino-2-methoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

1.2: 3 h / 60 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

2.2: pH 12

With 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;