(1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane

Base Information

• Chemical Name: (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane
• CAS No.: 88726-10-7
• Molecular Formula: C₁₃H₂₆O₂
• Molecular Weight: 214.348
• Mol file: 88726-10-7.mol

Synonyms:(1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane

Chemical Property of (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane

There total 12 articles about (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4R,6R)-2-cycloxexyl-2,4,6-trimethyl-1,3-dioxane (97928-62-6) → (2R,4R)-4-(1-Cyclohexyl-ethoxy)-pentan-2-ol (88726-10-7,88764-87-8)

Guidance literature:

With triethylsilane; potassium fluoride; titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.666667h; Product distribution; multistep reaction, 1.) CH₂Cl₂, -78 deg C, 0.5 h; 2.) methanol, 2 h. Stereoselectivity investigated varying Lewis acid and hydride reagent and reaction conditions;

DOI:10.1016/S0040-4020(01)90009-2

Reference yield:

dimethyldichlorotitanium(IV) (35739-70-9) + (4R,6R)-2-cyclohexyl-4,6-dimethyl-1,3-dioxane (85029-00-1) → (1S,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane (88764-87-8) + (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane (88726-10-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.5h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(01)81455-6

Reference yield:

trimethylaluminum (75-24-1) + (4R,6R)-2-cyclohexyl-4,6-dimethyl-1,3-dioxane (85029-00-1) → (1S,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane (88764-87-8) + (1R,1'R,3'R)-1-cyclohexyl-1-(3'-hydroxy-1'-methylbutoxy)ethane (88726-10-7)

Guidance literature:

In hexane; dichloromethane; at 49 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00076a030

upstream raw materials:

trimethylaluminum

(4R,6R)-2-cyclohexyl-4,6-dimethyl-1,3-dioxane

Methyl-titan-tribromid

dimethyldichlorotitanium(IV)

Downstream raw materials:

(R)-1-cyclohexylethanol

(S)-(+)-1-cyclohexylethanol