Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

Base Information

Chemical Name:Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester
CAS No.:105015-01-8
Molecular Formula:C₅₆H₅₀ClN₆O₁₂P
Molecular Weight:1065.47
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

Synonyms:Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

There total 7 articles about Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 71933-71-6
O-8-(5-chloroquinolyl) phosphate

: 105014-98-0
N-{9-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(3,4-dimethoxy-benzyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 105015-01-8
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

Guidance literature:: With quinoline-8-sulfonyl chloride; In pyridine; for 2h;
DOI:10.1246/cl.1986.1005

Reference yield:

: 21852-32-4
4-bromomethyl-1,2-dimethoxybenzene

: 105015-01-8
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / NaH / dimethylformamide

2: 83 percent

3: pyridine

4: 92 percent / 8-quinoline-sulfonyl chloride / pyridine / 2 h

With quinoline-8-sulfonyl chloride; sodium hydride; In pyridine; N,N-dimethyl-formamide;
DOI:10.1246/cl.1986.1005

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 105015-01-8
Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 92 percent / 8-quinoline-sulfonyl chloride / pyridine / 2 h

With quinoline-8-sulfonyl chloride; In pyridine;
DOI:10.1246/cl.1986.1005