105014-98-0

Upstream product

• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 105014-93-5 (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-4-(3,4-dimethoxy-benzyloxy)-2-hydroxymethyl-tetrahydro-furan-3-ol 
• 58-61-7 adenosine 
• 98-88-4 benzoyl chloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 105014-97-9 N-{9-[(2R,3R,4R,5R)-3-(3,4-Dimethoxy-benzyloxy)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Downstream Products

• 105015-01-8 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3,4-dimethoxy-benzyloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 

Relevant academic research and scientific papers

USE OF 3,4-DIMETHOXYBENZYL GROUP AS A PROTECTING GROUP FOR THE 2'-HYDROXYL GROUP IN THE SYNTHESIS OF OLIGORIBONUCLEOTIDES

The 3,4-dimethoxybenzyl group was introduced to the 2'-hydroxyl group by the reaction of nucleosides with 3,4-dimethoxybenzyl trichloroacetimidate or 3,4-dimethoxybenzyl bromide-NaH.Further, this group can be used as a protecting group for the O6-amide group of the guanine residue.The protected nucleosides are useful starting materials for the synthesis of oligoribonucleotides.The 3,4-dimethoxybenzyl group was removed rapidly from the oligoribonucleotides by treatment with oxidizing agents without any damage to the glycosidic bonds.