N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

Base Information

Chemical Name:N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide
CAS No.:1013417-92-9
Molecular Formula:C₁₈H₁₅F₇N₂O
Molecular Weight:408.319
Hs Code.:

Synonyms:N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

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Chemical Property of N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

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Technology Process of N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

There total 5 articles about N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1013417-85-0
2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-benzoyl chloride

: 108-45-2,64554-26-3,76583-20-5
m-phenylenediamine

: 1013417-92-9
N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

Guidance literature:: 2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-benzoyl chloride; m-phenylenediamine; In tetrahydrofuran; at 70 ℃; for 48h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 353272-62-5
2-iodo-1,3-dimethyl-5-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-benzene

: 1013417-92-9
N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 9 h / 115 °C / 82508.3 Torr

2.1: sodium hydroxide; water / 1,4-dioxane; methanol / 15 h / 60 °C

2.2: 0 °C / pH 1

3.1: thionyl chloride / 16 h / 85 °C

4.1: tetrahydrofuran / 48 h / 70 °C

With sodium hydroxide; thionyl chloride; water; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 273735-43-6
4-heptafluoroisopropyl-2,6-dimethylaniline

: 1013417-92-9
N-(3-amino-phenyl)-2,6-dimethyl-4-(1,2,2,2-tetrafluoro-l-trifluoromethyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 1 h / 0 °C

1.2: 0.25 - 0.33 h / 90 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 9 h / 115 °C / 82508.3 Torr

3.1: sodium hydroxide; water / 1,4-dioxane; methanol / 15 h / 60 °C

3.2: 0 °C / pH 1

4.1: thionyl chloride / 16 h / 85 °C

5.1: tetrahydrofuran / 48 h / 70 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; water; acetic acid; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; water;