N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

Base Information

Chemical Name:N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide
CAS No.:1359938-05-8
Molecular Formula:C₂₇H₃₃ClN₄O₄S
Molecular Weight:545.102
Hs Code.:

Synonyms:N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

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Chemical Property of N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

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Technology Process of N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

There total 6 articles about N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4300-97-4
3-Chloropivaloyl chloride

: 1359938-01-4
N-(2-(2-amino-3-benzyl-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide

: 1359938-05-8
N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

Guidance literature:: With diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: cis-ethyl 1-benzyl-6-methoxy-2,3-dihydro-1H-inden-2-ylcarbamate

: 1359938-05-8
N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / Inert atmosphere

1.2: Cooling with ice

2.1: caesium carbonate / acetonitrile / 1 h / 80 °C / Inert atmosphere

2.2: 2 h / 50 - 80 °C

3.1: formic acid / 20 °C

4.1: dmap / dichloromethane / 20 °C

5.1: potassium hydroxide / ethanol / 1 h / 100 °C / Microwave irradiation

6.1: diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; formic acid; boron tribromide; caesium carbonate; diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1359937-93-1
ethyl 1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-ylcarbamate

: 1359938-05-8
N-(1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-yl)-3-chloro-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 1 h / 100 °C / Microwave irradiation

2: diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With diisopropylamine; potassium hydroxide; In ethanol; dichloromethane;