Technology Process of 2-((2S,6S)-2,6-Diphenyl-piperidin-4-yl)-ethanol
There total 5 articles about 2-((2S,6S)-2,6-Diphenyl-piperidin-4-yl)-ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium n-propylmercaptide;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
at 23 ℃;
for 18h;
DOI:10.1016/S0040-4039(01)93481-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / zinc bromide / CH2Cl2 / 1 h / 23 °C
2: 77 percent / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) 0 deg C, 30 min
3: 95 percent / boron trifluoride etherate / toluene / 0.5 h / -30 - 23 °C
4: 1.) H2, 2.) H2 / 1.) Pd/C 2.) Pd/C / 1.) EtOAc, 23 deg C, 18 h, 2.) MeOH, 0.1 N HCl
5: 85 percent / lithium n-propylmercaptide (n-PrSLi) / hexamethylphosphoric acid triamide / 18 h / 23 °C
With
hydrogen; lithium n-propylmercaptide;
palladium on activated charcoal; boron trifluoride diethyl etherate; zinc dibromide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
DOI:10.1016/S0040-4039(01)93481-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / boron trifluoride etherate / toluene / 0.5 h / -30 - 23 °C
2: 1.) H2, 2.) H2 / 1.) Pd/C 2.) Pd/C / 1.) EtOAc, 23 deg C, 18 h, 2.) MeOH, 0.1 N HCl
3: 85 percent / lithium n-propylmercaptide (n-PrSLi) / hexamethylphosphoric acid triamide / 18 h / 23 °C
With
hydrogen; lithium n-propylmercaptide;
palladium on activated charcoal; boron trifluoride diethyl etherate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
DOI:10.1016/S0040-4039(01)93481-1
