Technology Process of (2R,6R)-4-(2-Hydroxy-ethyl)-2,6-diphenyl-piperidine-1-carboxylic acid methyl ester
There total 4 articles about (2R,6R)-4-(2-Hydroxy-ethyl)-2,6-diphenyl-piperidine-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,6R)-4-(2-Benzyloxy-ethyl)-2,6-diphenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester;
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 23 ℃;
for 18h;
under 760.051 Torr;
With
hydrogenchloride;
In
methanol; water; ethyl acetate;
at 23 ℃;
for 6h;
DOI:10.1021/ol100426m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / zinc bromide / CH2Cl2 / 1 h / 23 °C
2: 77 percent / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) 0 deg C, 30 min
3: 95 percent / boron trifluoride etherate / toluene / 0.5 h / -30 - 23 °C
4: 1.) H2, 2.) H2 / 1.) Pd/C 2.) Pd/C / 1.) EtOAc, 23 deg C, 18 h, 2.) MeOH, 0.1 N HCl
With
hydrogen;
palladium on activated charcoal; boron trifluoride diethyl etherate; zinc dibromide;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0040-4039(01)93481-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / boron trifluoride etherate / toluene / 0.5 h / -30 - 23 °C
2: 1.) H2, 2.) H2 / 1.) Pd/C 2.) Pd/C / 1.) EtOAc, 23 deg C, 18 h, 2.) MeOH, 0.1 N HCl
With
hydrogen;
palladium on activated charcoal; boron trifluoride diethyl etherate;
In
toluene;
DOI:10.1016/S0040-4039(01)93481-1
