(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate

Base Information

• Chemical Name: (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate
• CAS No.: 773894-72-7
• Molecular Formula: C₃₉H₃₈N₂O₆
• Molecular Weight: 630.741

Synonyms:(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate

Chemical Property of (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate

Chemical Property:

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Technology Process of (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate

There total 2 articles about (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-aminooctahydroindole-1,2,7-tricarboxylate (773894-74-9) + 9-bromo-9-phenyl-9H-fluorene (55135-66-5) → (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate (773894-72-7)

Guidance literature:

With lead(II) nitrate; triethylamine; In dichloromethane; for 20h;

DOI:10.1021/ol048585f

Reference yield:

(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-azidooctahydroindole-1,2,7-tricarboxylate (773894-71-6) → (2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate (773894-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Zn / acetic acid; tetrahydrofuran / 0.75 h

2: 62 percent / Pb(NO₃)2; Et₃N / CH₂Cl₂ / 20 h

With lead(II) nitrate; triethylamine; zinc; In tetrahydrofuran; dichloromethane; acetic acid;

DOI:10.1021/ol048585f

Reference yield: 86.0%

(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydroindole-1,2,7-tricarboxylate (773894-72-7) → (2S,4R,7R,9R)-1-((benzyloxy)carbonyl)-7-(methoxycarbonyl)-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydro-1H-indole-2-carboxylic acid (773894-68-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 24h;

DOI:10.1021/ol048585f

upstream raw materials:

(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-aminooctahydroindole-1,2,7-tricarboxylate

9-bromo-9-phenyl-9H-fluorene

(2S,4R,7R,9R)-1-benzyl-2,7-dimethyl-7-azidooctahydroindole-1,2,7-tricarboxylate

Downstream raw materials:

(2S,4R,7R,9R)-1-((benzyloxy)carbonyl)-7-(methoxycarbonyl)-7-(9-phenyl-9H-fluoren-9-ylamino)-octahydro-1H-indole-2-carboxylic acid

(2S,3aR,6R,7aR)-2-((3S,5S)-5-Carbamoyl-3-methoxycarbonyl-pyrrolidin-3-ylcarbamoyl)-6-{[(3S,5S,8S)-8-(4-hydroxy-benzyl)-7,10-dioxo-2,6,9-triaza-spiro[4.5]decane-3-carbonyl]-amino}-octahydro-indole-6-carboxylic acid methyl ester

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