(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

Base Information

Chemical Name:(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone
CAS No.:82932-68-1
Molecular Formula:C₁₇H₃₂O₂Si
Molecular Weight:296.525
Hs Code.:

Synonyms:(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

Chemical Property:

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Technology Process of (R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

There total 2 articles about (R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 82919-05-9
(R)-2-Cyclohexyl-1-cyclopropyl-2-hydroxy-ethanone

: 82932-68-1
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

Guidance literature:: With 1H-imidazole; dmap; In tetrahydrofuran; at 70 ℃; for 12h; Yield given;
DOI:10.1021/ja00384a060

Reference yield:

: 53585-93-6
(R)-(-)-hexahydromandelic acid

: 82932-68-1
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 1.) -78 deg C, 2 h, 2.) 0 deg C, 6 h

2: imidazole, DMAP / tetrahydrofuran / 12 h / 70 °C

With 1H-imidazole; dmap; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00384a060

Reference yield:

: 82932-68-1
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclohexyl-1-cyclopropyl-ethanone

: 82919-09-3
(1R,3S,4R)-1-Cyclohexyl-1,4-dihydroxy-3-vinyl-hexan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / 12-crown-4 / benzene / 18 h / 70 °C

2: 97 percent / (c-C₅H₉)2BOTf, (2-C₃H₇)2NEt / CH₂Cl₂ / 2 h / 0 °C

3: conc. HF / acetonitrile / 4 h / Ambient temperature

4: ozone / CH₂Cl₂ / -78 °C

5: pyridine / hexane / 1 h / 50 °C

With pyridine; dicyclopentylboron trifluoromethanesulfonate; hydrogen fluoride; ozone; N-ethyl-N,N-diisopropylamine; (1,4,7,10-tetraoxacyclododecane); In hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ja00384a060