(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Base Information

Chemical Name:(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene
CAS No.:873567-12-5
Molecular Formula:C₄₇H₈₈O₄Si₂
Molecular Weight:773.384
Hs Code.:

(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Synonyms:(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Suppliers and Price of (1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

There total 4 articles about (1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 873567-08-9
de-A,B-25-[(methoxymethyl)oxy]-cholestan-8-one

: Trifluoro-methanesulfonic acid (2S,4R)-1-methylene-2,4-bis-triisopropylsilanyloxy-hept-6-ynyl ester

: 873567-12-5
(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: de-A,B-25-[(methoxymethyl)oxy]-cholestan-8-one; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.5h;

With zinc dibromide; In tetrahydrofuran; diethyl ether; pentane; at -78 - -10 ℃;

Trifluoro-methanesulfonic acid (2S,4R)-1-methylene-2,4-bis-triisopropylsilanyloxy-hept-6-ynyl ester; With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; pentane; at -40 - 20 ℃;
DOI:10.1021/ol052489c

Reference yield:

: 33813-99-9
Grundmann's alcohol

: 873567-12-5
(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / (trifluoromethyl)methyldioxirane / CH₂Cl₂ / 2 h / -20 °C

2.1: 96 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: HMDS / tetrahydrofuran / 2 h / -60 °C

3.2: 60 percent / tetrahydrofuran / 17 h / -60 - -5 °C

4.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C

4.2: ZnBr₂ / tetrahydrofuran; diethyl ether; pentane / -78 - -10 °C

4.3: 75 percent / Et₃N / (Ph₃P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C

With dmap; (trifluoromethyl)methyldioxirane; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; dichloromethane; pentane; 4.3: Negishi cross-coupling;
DOI:10.1021/ol052489c

Reference yield:

: 70550-73-1
(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one

: 873567-12-5
(1R,3aS,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: HMDS / tetrahydrofuran / 2 h / -60 °C

2.2: 60 percent / tetrahydrofuran / 17 h / -60 - -5 °C

3.1: t-BuLi / diethyl ether; pentane / 0.5 h / -78 °C

3.2: ZnBr₂ / tetrahydrofuran; diethyl ether; pentane / -78 - -10 °C

3.3: 75 percent / Et₃N / (Ph₃P)4Pd / tetrahydrofuran; diethyl ether; pentane / -40 - 20 °C

With dmap; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; dichloromethane; pentane; 3.3: Negishi cross-coupling;
DOI:10.1021/ol052489c