C₁₇H₁₇N₃O

Base Information

• Chemical Name: C₁₇H₁₇N₃O
• CAS No.: 1420626-92-1
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.341
• Mol file: 1420626-92-1.mol

Synonyms:C₁₇H₁₇N₃O

Chemical Property of C₁₇H₁₇N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₇N₃O

There total 15 articles about C₁₇H₁₇N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H15N5O (1420830-43-8) → C17H17N3O (1420626-92-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h; under 760.051 Torr;

Reference yield:

ethyl isopropylidenecyanoacetate (759-58-0) → C17H17N3O (1420626-92-1)

Guidance literature:

Multi-step reaction with 14 steps

1.1: ethanol / 6 h / 760.05 Torr / Reflux

2.1: hydrogen bromide; acetic acid / 2 h / 40 - 55 °C / 760.05 Torr

2.2: 760.05 Torr / Cooling with ice

3.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 760.05 Torr / Reflux

3.2: 760.05 Torr / pH 1

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / 760.05 Torr

5.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / 760.05 Torr

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / 760.05 Torr / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / 760.05 Torr

7.2: 2 h / 760.05 Torr

8.1: osmium(VIII) oxide / water; 1,4-dioxane / 0.5 h / 20 °C / 760.05 Torr

8.2: 16 h / 20 °C / 760.05 Torr

9.1: caesium carbonate / ethanol; ethyl acetate / 2 h / 50 °C / 760.05 Torr

10.1: sodium tetrahydroborate; methanol / 16 h / 20 °C / 760.05 Torr

10.2: 760.05 Torr

11.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 16 h / 20 °C / 760.05 Torr / Molecular sieve

12.1: tetrahydrofuran / -78 °C / 760.05 Torr / Inert atmosphere

12.2: 760.05 Torr

13.1: triphenylphosphine / tetrahydrofuran / 0.08 h / 0 °C / 760.05 Torr / Inert atmosphere

13.2: 2.33 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

14.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr

With methanol; sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; sodium hydride; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

C18H18N2O4 (1420830-38-1) → C17H17N3O (1420626-92-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: caesium carbonate / ethanol; ethyl acetate / 2 h / 50 °C / 760.05 Torr

2.1: sodium tetrahydroborate; methanol / 16 h / 20 °C / 760.05 Torr

2.2: 760.05 Torr

3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 16 h / 20 °C / 760.05 Torr / Molecular sieve

4.1: tetrahydrofuran / -78 °C / 760.05 Torr / Inert atmosphere

4.2: 760.05 Torr

5.1: triphenylphosphine / tetrahydrofuran / 0.08 h / 0 °C / 760.05 Torr / Inert atmosphere

5.2: 2.33 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr

With methanol; sodium tetrahydroborate; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; caesium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;

upstream raw materials:

C₁₈H₁₈N₂O₄

ethyl isopropylidenecyanoacetate

1-carbethoxy-1-cyano-2-methyl-4-dimethylamino-1,4-butadiene

ethyl 2-bromo-4-methylnicotinic acid