N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

Base Information

Chemical Name:N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide
CAS No.:1373521-09-5
Molecular Formula:C₂₇H₃₁ClN₄OS
Molecular Weight:495.088
Hs Code.:

Synonyms:N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

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Chemical Property of N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

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Technology Process of N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

There total 2 articles about N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 39546-47-9
p-chlorobenzylisocyanide

: 107-11-9,30551-89-4
1-amino-2-propene

: 31167-21-2
2-(benzylthio)pyrimidin-4-ol

: 590-86-3
isovaleraldehyde

: 1373521-09-5
N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

Guidance literature:: In methanol; Inert atmosphere; Reflux;
DOI:10.1055/s-0031-1290347

Reference yield:

: 100-44-7
benzyl chloride

: 1373521-09-5
N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / water / 3 h / Reflux

2: methanol / Inert atmosphere; Reflux

With potassium carbonate; In methanol; water; 2: Ugi-Smiles coupling reaction;
DOI:10.1055/s-0031-1290347

Reference yield: 87.0%

: 1373521-09-5
N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

: N-(4-chlorobenzyl)-2-(allyl(2-(benzylsulfonyl)pyrimidin-4-yl)amino)-4-methylpentanamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2018.04.058