N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

Base Information

Chemical Name:N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide
CAS No.:1373521-41-5
Molecular Formula:C₂₇H₃₁Cl₂N₅O
Molecular Weight:512.482
Hs Code.:

Synonyms:N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

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Chemical Property of N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

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Technology Process of N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

There total 4 articles about N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1373521-09-5
N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

: 104-86-9
4-chlorobenzylamine

: 1373521-41-5
N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

Guidance literature:: N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene; at 20 ℃; for 2h; Inert atmosphere;

4-chlorobenzylamine; In dichloromethane; toluene; at 20 - 110 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2018.04.058

Reference yield:

: 1373521-09-5
N-(4-chlorobenzyl)-2-(allyl(2-(benzylthio)pyrimidin-4-yl)amino)-4-methylpentanamide

: 1373521-41-5
N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; toluene / 2 h / 20 °C / Inert atmosphere

2: dichloromethane; toluene / 7.33 h / 20 - 110 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;
DOI:10.1055/s-0031-1290347

Reference yield:

: 590-86-3
isovaleraldehyde

: 1373521-41-5
N-(4-chlorobenzyl)-2-((2-(4-chlorobenzylamino)pyrimidin-4-yl)(allyl)amino)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / Inert atmosphere; Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane; toluene / 2 h / 20 °C / Inert atmosphere

3: dichloromethane; toluene / 7.33 h / 20 - 110 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; toluene; 1: Ugi-Smiles coupling reaction;
DOI:10.1055/s-0031-1290347