N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

Base Information

Chemical Name:N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide
CAS No.:1609158-96-4
Molecular Formula:C₂₄H₁₄F₆N₂O
Molecular Weight:460.378
Hs Code.:

Synonyms:N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

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Technology Process of N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

There total 1 articles about N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 75358-95-1
pyridine-2-carboxylic acid naphthalen-1-ylamide

: 328-73-4
3,5-bis(trifluoromethyl)iodobenzene

: 1609158-96-4
N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

Guidance literature:: With silver(I) acetate; palladium diacetate; at 140 ℃; for 13h; Inert atmosphere;
DOI:10.1021/ja502130w

Reference yield: 94.0%

: 1609158-96-4
N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

: 79-22-1
methyl chloroformate

: 1609158-97-5
methyl N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}-N-[(pyridin-2-yl)carbonyl]carbamate

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ja502130w

Reference yield:

: 1609158-96-4
N-{8-[3,5-bis(trifluoromethyl)phenyl]naphthalen-1-yl}pyridine-2-carboxamide

: 1609158-94-2
C₄₈H₂₄Br₂F₁₂N₂Ni

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 0 - 20 °C / Inert atmosphere

3: potassium hydroxide; water / 12 h / 100 °C / Inert atmosphere

4: formic acid / methanol / 14.5 h / 20 °C / Reflux; Inert atmosphere

5: dichloromethane / 24 h / Schlenk technique; Inert atmosphere

With sodium tetrahydroborate; formic acid; water; sodium hexamethyldisilazane; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ja502130w