(S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Base Information

• Chemical Name: (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester
• CAS No.: 83552-43-6
• Molecular Formula: C₂₃H₃₂N₂O₅S₂
• Molecular Weight: 480.649
• Mol file: 83552-43-6.mol

Synonyms:(S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Chemical Property of (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

There total 3 articles about (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyloxycarbonyl-4-keto-L-proline (64187-47-9) → (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester (83552-43-6)

Guidance literature:

Multi-step reaction with 4 steps

1: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

2: HCl / acetic acid / 1 h / Heating

3: HCl / 1.) -30 deg C, 2 h, 2.) room temperature, 24 h

4: diphenyl phosphorazidate, Et₃N / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature, 19 h

With hydrogenchloride; diphenyl phosphoryl azide; boron trifluoride diethyl etherate; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00401a014

Reference yield:

7-<(phenylmethoxy)carbonyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid (75776-77-1) → (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester (83552-43-6)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / acetic acid / 1 h / Heating

2: HCl / 1.) -30 deg C, 2 h, 2.) room temperature, 24 h

3: diphenyl phosphorazidate, Et₃N / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature, 19 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00401a014

Reference yield:

(S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride (83552-41-4) → (S)-7-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester (83552-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 1.) -30 deg C, 2 h, 2.) room temperature, 24 h

2: diphenyl phosphorazidate, Et₃N / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature, 19 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00401a014

upstream raw materials:

7-<(phenylmethoxy)carbonyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

(S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride

1-benzyloxycarbonyl-4-keto-L-proline

Downstream raw materials:

Spiraprilat