(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

Base Information

Chemical Name:(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester
CAS No.:109318-17-4
Molecular Formula:C₂₉H₄₀N₄O₆
Molecular Weight:540.66
Hs Code.:

Synonyms:(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

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Chemical Property of (R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

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Technology Process of (R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

There total 2 articles about (R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94236-47-2
N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide

: 109318-17-4
(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile; H₂O / 3 h / Ambient temperature

2: DIEA / dimethylformamide / 2 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00388a002

Reference yield:

: (S)-3-Amino-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester; compound with trifluoro-acetic acid

: 3173-56-6
benzyl isothiocyanate

: 109318-17-4
(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00388a002

Reference yield:

: 109318-17-4
(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester

: (R)-3-(3-Benzyl-ureido)-3-{(S)-2-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoylamino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic acid, 2.) DIEA / 1.) 30 min, 2.) DMF, RT, 2 h

2: 80 percent / H₂ / 10percent Pd/C / ethanol; dimethylformamide / 4 h / 760 Torr / Ambient temperature

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00388a002