N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide
• CAS No.: 94236-47-2
• Molecular Formula: C₂₂H₃₃N₃O₆
• Molecular Weight: 435.521
• Mol file: 94236-47-2.mol

Synonyms:N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide

Chemical Property of N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide

There total 2 articles about N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(tert-butoxycarbonyl)-L-leucine p-nitrobenzylester (3350-19-4) + β-benzyl-L-aspartic acid amide trifluoroacetate (92762-94-2) → N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide (94236-47-2)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00381a002

Reference yield:

Boc-Leu-ONSu (3392-09-4) + β-benzyl-L-aspartic acid amide trifluoroacetate (92762-94-2) → N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide (94236-47-2)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1.) DMF, 20 deg C, 20 min, 2.) a) 0 deg C, 1 h, b) 20 deg C, 1 d;

DOI:10.1007/BF00766860

Reference yield: 86.0%

N-tert-butoxycarbonyl-L-leucyl-β-benzyl-L-asparaginic acid α-amide (94236-47-2) + trifluoroacetic acid (76-05-1) → L-leucyl-β-benzyl-L-asparaginic acid α-amide trifluoroacetate (129280-61-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1007/BF00766860

upstream raw materials:

Boc-Leu-ONSu

β-benzyl-L-aspartic acid amide trifluoroacetate

(tert-butoxycarbonyl)-L-leucine p-nitrobenzylester

Downstream raw materials:

L-leucyl-β-benzyl-L-asparaginic acid α-amide trifluoroacetate

(R)-3-(3-Benzyl-ureido)-3-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid benzyl ester