1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Name:1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1001414-28-3
Molecular Formula:C₃₃H₂₄F₂N₄O₅S
Molecular Weight:626.64
Hs Code.:

Synonyms:1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of 1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of 1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 13 articles about 1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1001414-27-2
1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 1001414-28-3
1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 880769-95-9
3-bromo-1-(benzenesulfonyl)-1H-pyrrolo [2,3-b]pyridine

: 1001414-28-3
1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave on 50 watts

2: hydroxylamine hydrochloride / methanol

3: acetic acid; zinc / 100 °C / Heating / reflux

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

5: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

With aluminum (III) chloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 271-63-6
7-Azaindole

: 1001414-28-3
1-(3,4-difluorobenzyl)-N-(3-hydroxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 0 °C

2.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran / 0 °C

2.2: 20 °C

3.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave on 50 watts

4.1: hydroxylamine hydrochloride / methanol

5.1: acetic acid; zinc / 100 °C / Heating / reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

7.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

With aluminum (III) chloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;