methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

Base Information

Chemical Name:methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate
CAS No.:291534-08-2
Molecular Formula:C₂₆H₂₈N₂O₆S
Molecular Weight:496.584
Hs Code.:

Synonyms:methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

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Technology Process of methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

There total 4 articles about methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 110-91-8,99108-56-2
morpholine

: 1062537-39-6
2-[4-(4-methoxy-phenylethynyl)-benzenesulfonylamino]-pent-4-ynoic acid methyl ester

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 291534-08-2
methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

Guidance literature:: With copper acetylacetonate; In 1,4-dioxane; at 90 ℃;
DOI:10.1021/jm000477l

Reference yield:

: 50428-03-0
D,L-propargylglycine

: 291534-08-2
methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 16 h

2: triethylamine / dioxane; H₂O / 20 °C

3: 63 percent / Cu(acac)2 / dioxane / 90 °C

With copper acetylacetonate; thionyl chloride; triethylamine; In 1,4-dioxane; water; 1: Williams esterification / 2: Schotten-Baumann reaction / 3: Mannich reaction;
DOI:10.1021/jm000477l

Reference yield:

: 70837-20-6
propargyclycine methyl ester hydrochloride

: 291534-08-2
methyl 2-[4-(4-Methoxyphenyl)-acetylenylbenzenesulfonyl]-amino-6-morpholinohex-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dioxane; H₂O / 20 °C

2: 63 percent / Cu(acac)2 / dioxane / 90 °C

With copper acetylacetonate; triethylamine; In 1,4-dioxane; water; 1: Schotten-Baumann reaction / 2: Mannich reaction;
DOI:10.1021/jm000477l