2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt
CAS No.:1426802-39-2
Molecular Formula:C₂HF₃O₂*C₂₇H₂₂F₃N₃O₄S
Molecular Weight:655.575
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Suppliers and Price of 2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

There total 6 articles about 2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1426804-86-5
2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylamine

: 76-05-1
trifluoroacetic acid

: 1426802-39-2
2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Guidance literature:: 2-[4-(ethanesulfonyl)phenyl]acetic acid; 2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylamine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

trifluoroacetic acid;
DOI:10.1021/acsmedchemlett.5b00122

Reference yield:

: 175676-65-0
2-trifluoromethoxyphenylboronic acid

: 1426802-39-2
2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 1 h / 90 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; XPhos; In 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.5b00122

Reference yield:

: 2-chloro-4-nitro-2’-trifluoromethoxy-1,1’-biphenyl

: 1426802-39-2
2-[4-(ethylsulfonyl)phenyl]-N-{2-(5-pyrimidinyl)-2'-[(trifluoromethyl)oxy]-4-biphenylyl}acetamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 1 h / 90 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; XPhos; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/acsmedchemlett.5b00122