tert-Butyl 2-(3-aminophenyl)acetate

Base Information

• Chemical Name: tert-Butyl 2-(3-aminophenyl)acetate
• CAS No.: 183180-53-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 183180-53-2.mol

Synonyms:tert-Butyl 2-(3-aminophenyl)acetate

Chemical Property of tert-Butyl 2-(3-aminophenyl)acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 2-(3-aminophenyl)acetate

There total 5 articles about tert-Butyl 2-(3-aminophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-nitrophenylacetic acid t-butyl ester (180150-74-7) → tert-Butyl 2-(3-aminophenyl)acetate (183180-53-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h;

DOI:10.1021/jm980072p

Reference yield: 83.0%

tert-butoxycarbonylmethylzinc bromide tetrahydrofuran salt + m-Bromoaniline (591-19-5) → tert-Butyl 2-(3-aminophenyl)acetate (183180-53-2)

Guidance literature:

m-Bromoaniline; With potassium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

tert-butoxycarbonylmethylzinc bromide tetrahydrofuran salt; With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo401476f

Reference yield:

3-nitro-benzeneacetic acid (1877-73-2) → tert-Butyl 2-(3-aminophenyl)acetate (183180-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Boc₂O, DMAP

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

With dmap; di-tert-butyl dicarbonate; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm980072p

upstream raw materials:

3-nitrophenylacetic acid t-butyl ester

3-nitro-benzeneacetic acid

3-amino-1-ethoxycarbonylmethyl-5-phenyl-2,3-dihydro-1H-1-benzazepin-2-one

m-Bromoaniline

Downstream raw materials:

3-nitrosophenylacetic acid tert-butyl ester

tert-Butyl 2-[3-[3-[N-[3-[N-ethyl-N-(3,5-dimethylphenyl)carbamoylmethyloxy]phenyl]-N-(N-methyl-N-phenylcarbamoylmethyl)carbamoylmethyl]ureido]phenyl] acetate