3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

Base Information

Chemical Name:3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde
CAS No.:1253733-87-7
Molecular Formula:C₂₃H₂₂BrF₂N₃O₂Si
Molecular Weight:518.433
Hs Code.:

Synonyms:3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

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Chemical Property of 3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

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Technology Process of 3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

There total 7 articles about 3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253733-86-6
3-bromo-5-(2,6-difluorophenyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1253733-88-8
3-bromo-5-(2,6-difluorophenyl)-2-(2-trimethylsilanylethoxymethyl)-2H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

: 1253733-87-7
3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253733-88-8
3-bromo-5-(2,6-difluorophenyl)-2-(2-trimethylsilanylethoxymethyl)-2H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

: 1253733-87-7
3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 0.17 h / Inert atmosphere

4.2: 1 h / 100 °C

4.3: 0.5 h / 20 °C

5.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran / 3 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium periodate; osmium(VIII) oxide; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253733-88-8
3-bromo-5-(2,6-difluorophenyl)-2-(2-trimethylsilanylethoxymethyl)-2H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

: 1253733-87-7
3-bromo-5-(2,6-difluorophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 0.17 h / Inert atmosphere

4.2: 1 h / 100 °C

4.3: 0.5 h / 20 °C

5.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran / 3 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium periodate; osmium(VIII) oxide; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;