Technology Process of methyl N-[[5-[1-(4-methoxy-2-methylphenyl)-1H-1,2,4-triazol-3-yl]-2-methylphenyl]methyl]carbamate
There total 7 articles about methyl N-[[5-[1-(4-methoxy-2-methylphenyl)-1H-1,2,4-triazol-3-yl]-2-methylphenyl]methyl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; N,N’-trans-dimethyl cyclohexane-1,2-diamine;
In
1,4-dioxane;
at 100 ℃;
for 48h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 35 - 60 °C
2.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 - 5 °C
3.1: N,N-dimethyl-formamide / 2 h / 35 - 55 °C
4.1: N,N-dimethyl-formamide / 16 h / 125 °C
5.1: dihydrogen peroxide; sodium hydroxide / water; ethanol / 16 h / 0 - 25 °C
6.1: toluene / 16 h / 100 °C
6.2: 3 h / 20 °C
7.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; N,N’-trans-dimethyl cyclohexane-1,2-diamine / 1,4-dioxane / 48 h / 100 °C / Inert atmosphere
With
copper(l) iodide; dimethylsulfide borane complex; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; N,N’-trans-dimethyl cyclohexane-1,2-diamine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 - 5 °C
2.1: N,N-dimethyl-formamide / 2 h / 35 - 55 °C
3.1: N,N-dimethyl-formamide / 16 h / 125 °C
4.1: dihydrogen peroxide; sodium hydroxide / water; ethanol / 16 h / 0 - 25 °C
5.1: toluene / 16 h / 100 °C
5.2: 3 h / 20 °C
6.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; N,N’-trans-dimethyl cyclohexane-1,2-diamine / 1,4-dioxane / 48 h / 100 °C / Inert atmosphere
With
copper(l) iodide; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; N,N’-trans-dimethyl cyclohexane-1,2-diamine;
In
1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;
