Technology Process of 3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

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Home > CAS Database list > 3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

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Chemical Name:3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate
CAS No.:1131041-78-5
Molecular Formula:C₃₉H₄₃ClN₈O₈S
Molecular Weight:819.338
Hs Code.:

3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

Synonyms:3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

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Chemical Property of 3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

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Technology Process of 3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

There total 1 articles about 3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₆BClN₄O₆

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: 1131041-62-7
5-bromo-3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazine

: 1131041-76-3
1,1-dimethylethyl [(1S)-2-({2-amino-6-chloro-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-77-4
1,1-dimethylethyl [(1S)-2-({2-(acetylamino)-6-chloro-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-75-2
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

: 1131041-78-5
3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

: 864776-02-3
4,4,5,5-tetramethyl-2-(2-methylfuran-3-yl)-1,3,2-dioxaborolane

: 1131041-76-3
1,1-dimethylethyl [(1S)-2-({2-amino-6-chloro-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-77-4
1,1-dimethylethyl [(1S)-2-({2-(acetylamino)-6-chloro-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-75-2
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

: 1131041-78-5
3-hydroxy-2,2-dimethylpropyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-2-pyridinyl}carbamate

: 1131041-79-6
1,1-dimethylethyl [(1S)-2-({2-amino-6-(2-methyl-3-furanyl)-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-80-9
1,1-dimethylethyl [(1S)-2-({2-(acetylamino)-6-(2-methyl-3-furanyl)-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

: 1131041-81-0
1,1-dimethylethyl [(1S)-2-({2-({[(3-hydroxy-2,2-dimethylpropyl)oxy]carbonyl}amino)-6-(2-methyl-3-furanyl)-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-3-pyridinyl}oxy)-1-(1H-indol-3-ylmethyl)ethyl]carbamate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 98 ℃; for 16h; Inert atmosphere;