2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol

Base Information

• Chemical Name: 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol
• CAS No.: 1286238-94-5
• Molecular Formula: C₁₂H₉F₇O
• Molecular Weight: 302.192
• Mol file: 1286238-94-5.mol

Synonyms:2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol

Chemical Property of 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol

There total 3 articles about 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + triethyl (1,1,2,2-tetrafluorobut-3-en-1-yl)silane (1286239-07-3) → 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol (1286238-94-5)

Guidance literature:

4-Trifluoromethylbenzaldehyde; triethyl (1,1,2,2-tetrafluorobut-3-en-1-yl)silane; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 12h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1055/s-0030-1258330

Reference yield: 37.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + 4-bromo-3,3,4,4-tetrafluorobut-1-ene (18599-22-9) → 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol (1286238-94-5)

Guidance literature:

4-Trifluoromethylbenzaldehyde; 4-bromo-3,3,4,4-tetrafluorobut-1-ene; In tetrahydrofuran; at -78 ℃; for 0.166667h;

With methyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1055/s-0030-1258330

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + triethyl (1,1,2,2-tetrafluorobut-3-en-1-yl)silane (1286239-07-3) → 2,2,3,3-tetrafluoro-1-[4-(trifluoromethyl)phenyl]pent-4-en-1-ol (1286238-94-5) + C18H23F7OSi

Guidance literature:

4-Trifluoromethylbenzaldehyde; triethyl (1,1,2,2-tetrafluorobut-3-en-1-yl)silane; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 12h;

DOI:10.1055/s-0030-1258330

upstream raw materials:

4-Trifluoromethylbenzaldehyde

triethyl (1,1,2,2-tetrafluorobut-3-en-1-yl)silane

4-bromo-3,3,4,4-tetrafluorobut-1-ene