(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Base Information

Chemical Name:(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin
CAS No.:1287708-92-2
Molecular Formula:C₃₀H₃₅NO₇S
Molecular Weight:553.676
Hs Code.:

Synonyms:(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Suppliers and Price of (10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Chemical Property:

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Technology Process of (10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

There total 6 articles about (10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 224638-42-0
(2E)-1-(4-hydroxyphenyl)-3-(thiophene-2-yl)prop-2-en-1-one

: 1287709-17-4
(10R)-N-chloroacetyl-aminodihydroartemisinin

: 1287708-92-2
(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1248/cpb.59.984

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 1287708-92-2
(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 60 °C

With potassium carbonate; sodium iodide; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; 1.2: Claisen-Schmidt condensation;
DOI:10.1248/cpb.59.984

Reference yield:

: 1119668-68-6
10-α-azidodihydroartemisinin

: 1287708-92-2
(10R)-N-{4-[3-(2-thienyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran / 2 h / 60 °C

2: triethylamine / dichloromethane / 20 °C / Cooling

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 60 °C

With potassium carbonate; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.59.984