(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

Base Information

Chemical Name:(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile
CAS No.:509083-46-9
Molecular Formula:C₁₈H₁₁Cl₂N₃O₂
Molecular Weight:372.21
Hs Code.:

Synonyms:(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

Suppliers and Price of (E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

There total 2 articles about (E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 105-07-7
4-cyanobenzaldehyde

: 27387-90-2
3-(3,5-dichlorophenyl)-1-methyl-2,4-imidazolidinedione

: 509083-46-9
(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

Guidance literature:: With 2-pyrrolidinon; In ethanol; for 20 - 24h; Heating / reflux;

Reference yield:

: 34893-92-0
3,4-dichlorophenyl isocyanate

: 509083-46-9
(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

1.2: 99 percent / CH₂Cl₂ / 20 °C

2.1: 85 percent / pyrrolidine; MgSO₄ / ethanol / 18 h / 78 °C

With pyrrolidine; magnesium sulfate; triethylamine; In ethanol; dichloromethane; 2.1: Knoevenagel condensation;
DOI:10.1021/jm0610806

Reference yield: 90.0%

: 509083-46-9
(E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile

: 100-97-0
hexamethylenetetramine

: 4-[(5S*,9R*)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]benzonitrile hydrochloride salt

Guidance literature:: (E)-4-((1-(3,5-dichlorophenyl)-3-methyl-2,5-dioxoimidazolidin-4-ylidene)methyl)benzonitrile; hexamethylenetetramine; With glycine; In 1-methyl-pyrrolidin-2-one; toluene; at 140 ℃; for 7 - 8h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; toluene; at 50 - 60 ℃; for 0.166667 - 0.25h;