N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester
CAS No.:774599-41-6
Molecular Formula:C₄₀H₄₅N₃O₆S
Molecular Weight:695.88
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

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Chemical Property of N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

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Technology Process of N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

There total 4 articles about N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 774599-40-5
S-trityl-L-cysteine-L-phenylalanine ethyl ester

: 4530-20-5
BOC-glycine

: 774599-41-6
N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1021/ol0490779

Reference yield:

: 774599-39-2
N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine-L-phenylalanine ethyl ester

: 774599-41-6
N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / piperidine / dimethylformamide / 0.5 h / 20 °C

2: 91 percent / PyBOP; HOBt; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 7 h / 20 °C

With piperidine; 2,4,6-trimethyl-pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0490779

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 774599-41-6
N-(tert-butoxycarbonyl)-glycine-S-trityl-L-cysteine-L-phenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / PyBOP; HOBt; 2,4,6-collidine / dimethylformamide; CH₂Cl₂ / 5 h / 20 °C

2: 93 percent / piperidine / dimethylformamide / 0.5 h / 20 °C

3: 91 percent / PyBOP; HOBt; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 7 h / 20 °C

With piperidine; 2,4,6-trimethyl-pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0490779