((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

Base Information

Chemical Name:((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester
CAS No.:75363-09-6
Molecular Formula:C₃₃H₃₃N₃O₁₂
Molecular Weight:663.638
Hs Code.:

Synonyms:((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

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Chemical Property of ((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

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Technology Process of ((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

There total 12 articles about ((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 66168-82-9
(S)-2-Benzyloxycarbonylamino-3-hydroxy-propionic acid (S)-2-benzyloxycarbonylamino-2-((S)-2-benzyloxycarbonylamino-2-carboxy-ethoxycarbonyl)-ethyl ester

: 66168-83-0,75363-09-6
((3S,7S,11S)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

Guidance literature:: With triphenylphosphine; bis(4-tert-butyl-1-iso-propyl-1H-imidazol-2-yl)disulfide; In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1021/jo00331a001

Reference yield: 10.0%

: 75299-19-3
(R)-2-Benzyloxycarbonylamino-3-hydroxy-propionic acid (R)-2-benzyloxycarbonylamino-2-((R)-2-benzyloxycarbonylamino-2-carboxy-ethoxycarbonyl)-ethyl ester

: 75363-09-6
((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

Guidance literature:: With triphenylphosphine; bis(4-tert-butyl-1-iso-propyl-1H-imidazol-2-yl)disulfide; In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1021/jo00331a001

Reference yield:

: 6081-61-4
N-(benzyloxycarbonyl)-D-serine

: 75363-09-6
((3R,7R,11R)-7,11-Bis-benzyloxycarbonylamino-2,6,10-trioxo-1,5,9-trioxa-cyclododec-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran / 0.5 h / Heating

2: pyridinium p-toluenesulfonate / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / N-methylmorpholine / propan-2-ol / 4 h / Irradiation

4: 100 percent / 1.) N-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, 2.) N-methylmorpholine / tetrahydrofuran / 1.) 1h, 5 deg C, 1h, r.t., 2.) 20h, r.t.

5: 95 percent / pyridinium p-toluenesulfonate / CHCl₃; ethanol / 23 h / 55 °C

6: 67 percent / N-methylmorpholine / propan-2-ol; CHCl₃ / 4.5 h / Irradiation

7: 10 percent / 4-tert-butyl-N-isopropylimidazolyl disulfide, triphenylphosphine / CH₂Cl₂ / 0.25 h / Ambient temperature

With 4-methyl-morpholine; pyridinium p-toluenesulfonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; triphenylphosphine; bis(4-tert-butyl-1-iso-propyl-1H-imidazol-2-yl)disulfide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1021/jo00331a001