4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Base Information

Chemical Name:4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1253573-79-3
Molecular Formula:C₂₂H₂₁N₇O
Molecular Weight:399.455
Hs Code.:

Synonyms:4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of 4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of 4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

There total 3 articles about 4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1253573-80-6
4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253573-79-3
4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With trifluorormethanesulfonic acid; trifluoroacetic acid; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm300184s

Reference yield:

: 1253573-75-9
4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253573-79-3
4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate monohydrate; XPhos / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

3: trifluorormethanesulfonic acid; trifluoroacetic acid / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate monohydrate; trifluorormethanesulfonic acid; trifluoroacetic acid; lithium hexamethyldisilazane; XPhos; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm300184s

Reference yield:

: 1253573-76-0
4-(5-chloro-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253573-79-3
4-(5-benzyl-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate monohydrate; XPhos / 1,4-dioxane; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: trifluorormethanesulfonic acid; trifluoroacetic acid / 16 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate monohydrate; trifluorormethanesulfonic acid; trifluoroacetic acid; XPhos; In 1,4-dioxane; water;
DOI:10.1021/jm300184s