4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Base Information

• Chemical Name: 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
• CAS No.: 1253573-75-9
• Molecular Formula: C₂₅H₂₃ClFN₅O₂
• Molecular Weight: 479.941

Synonyms:4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Chemical Property of 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Chemical Property:

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Technology Process of 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

There total 1 articles about 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(5-chloro-2-fluoropyridin-3-yl)boronic acid (937595-70-5) + 4-chloro-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazine-2-amine (1253569-14-0) → 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253573-75-9)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; In 1,4-dioxane; water; at 95 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm300184s

Reference yield: 88.0%

5-fluoro-6-methoxypyridin-3-ylamine (886372-63-0) + 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253573-75-9) → 4-(5-chloro-2-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253575-94-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃; for 0.666667h;

DOI:10.1021/jm300846z

Reference yield: 86.0%

6-methoxy-pyridin-3-ylamine (6628-77-9) + 4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253573-75-9) → 4-(5-chloro-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (1253573-76-0)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm300184s

upstream raw materials:

(5-chloro-2-fluoropyridin-3-yl)boronic acid

4-chloro-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazine-2-amine

Downstream raw materials:

4-(5-chloro-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

N,N-bis(4-methoxybenzyl)-4-(5-(methoxymethyl)-2-((6-methoxypyridin-3-yl)amino)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-morpholinopyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

4-(5-(3,6-dihydro-2H-pyran-4-yl)-2-(6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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