4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester

Base Information

• Chemical Name: 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester
• CAS No.: 740815-55-8
• Molecular Formula: C₁₅H₁₂F₃NO₄
• Molecular Weight: 327.26
• Mol file: 740815-55-8.mol

Synonyms:4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester

Chemical Property of 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester

There total 1 articles about 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-trifluoromethylbenzoic acid (455-24-3) + 1-(3-chloroacryloyl)-2-pyrrolidinone (740815-78-5) → 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester (740815-55-8)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2004.05.090

Reference yield:

7-methyl-3-methene-1,6-octadiene (123-35-3) + 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester (740815-55-8) → 4-trifluoromethyl-benzoic acid (1S,6S)-3-(4-methyl-pent-3-enyl)-6-(2-oxo-pyrrolidine-1-carbonyl)-cyclohex-3-enyl ester + 4-trifluoromethyl-benzoic acid (1R,6R)-3-(4-methyl-pent-3-enyl)-6-(2-oxo-pyrrolidine-1-carbonyl)-cyclohex-3-enyl ester

Guidance literature:

4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester; 1,1-bis(8,8a,3a-tri(H)-indeno[1,2-d]oxazol-2yl)cPr*Cu(SbF₆)2; In dichloromethane; at 20 ℃; for 0.5h;

7-methyl-3-methene-1,6-octadiene; In dichloromethane; at 20 ℃; for 144h; Further stages. Title compound not separated from byproducts.;

DOI:10.1016/j.tetlet.2004.05.090

Reference yield:

trans-2-methyl-1,3-pentadiene (926-54-5) + 4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester (740815-55-8) → 4-trifluoromethyl-benzoic acid (1S,5S,6S)-3,5-dimethyl-6-(2-oxo-pyrrolidine-1-carbonyl)-cyclohex-3-enyl ester + 4-trifluoromethyl-benzoic acid (1R,5R,6R)-3,5-dimethyl-6-(2-oxo-pyrrolidine-1-carbonyl)-cyclohex-3-enyl ester

Guidance literature:

4-trifluoromethylbenzoic acid 3-oxo-3-(2-oxo-pyrrolidin-3-yl)-propenyl ester; 1,1-bis(8,8a,3a-tri(H)-indeno[1,2-d]oxazol-2yl)cPr*Cu(SbF₆)2; In dichloromethane; at 20 ℃; for 0.5h;

trans-2-methyl-1,3-pentadiene; In dichloromethane; at 0 ℃; for 96h; Further stages. Title compound not separated from byproducts.;

DOI:10.1016/j.tetlet.2004.05.090

upstream raw materials:

4-trifluoromethylbenzoic acid

1-(3-chloroacryloyl)-2-pyrrolidinone

Downstream raw materials:

4-trifluoromethylbenzoic acid endo-3-(2-oxo-pyrrolidine-3-carbonyl)-bicyclo[2.2.1]hept-5-en-2-yl ester

3-(4-trifluoromethyl-benzoyloxy)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester