(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime

Base Information

• Chemical Name: (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime
• CAS No.: 1280635-08-6
• Molecular Formula: C₂₆H₂₄F₄N₂O
• Molecular Weight: 456.483
• Mol file: 1280635-08-6.mol

Synonyms:(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime

Chemical Property of (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime

There total 1 articles about (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime (1280635-01-9) + 4-trifluoromethylbenzyl chloride (939-99-1) → (Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime (1280635-08-6)

Guidance literature:

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

4-trifluoromethylbenzyl chloride; In N,N-dimethyl-formamide; at 50 ℃; for 120h;

DOI:10.1016/j.ejmech.2010.12.018

Reference yield:

(Z)-1-benzyl-4-(4-fluorophenyl)piperidin-3-one O-4-trifluoromethylbenzyl oxime (1280635-08-6) → (E)-4-(4-fluorophenyl)piperidin-3-one O-4-(trifluoromethyl)benzyl oxime hydrochloride (1280634-82-3) + (Z)-4-(4-fluorophenyl)piperidin-3-one O-4-(trifluoromethyl)benzyl oxime hydrochloride (1280634-83-4)

Guidance literature:

With hydrogenchloride; 10% palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 30h; under 760.051 Torr; pH=3; optical yield given as %de;

DOI:10.1016/j.ejmech.2010.12.018

upstream raw materials:

1-benzyl-4-(4-fluorophenyl)piperidin-3-one oxime

4-trifluoromethylbenzyl chloride

Downstream raw materials:

(E)-4-(4-fluorophenyl)piperidin-3-one O-4-(trifluoromethyl)benzyl oxime hydrochloride

(Z)-4-(4-fluorophenyl)piperidin-3-one O-4-(trifluoromethyl)benzyl oxime hydrochloride