tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

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Chemical Name:tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate
CAS No.:1610612-17-3
Molecular Formula:C₂₆H₂₃F₄N₃O₂
Molecular Weight:485.481
Hs Code.:

Synonyms:tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

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Chemical Property of tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

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Technology Process of tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

There total 5 articles about tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610612-14-0
tert-butyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

: 459-46-1
4-Fluorobenzyl bromide

: 1610612-17-3
tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

Guidance literature:: tert-butyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610612-17-3
tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

With diphenyl phosphoryl azide; sodium hydride; In N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

Reference yield:

: 705-31-7
4-trifluoromethylphenylacetylene

: 1610612-17-3
tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: water; sodium hydroxide / methanol; 1,4-dioxane / 3 h / 20 °C

3.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

With diphenyl phosphoryl azide; water; sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 3.1: |Curtius Rearrangement;