N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine
CAS No.:1610610-51-9
Molecular Formula:C₂₁H₁₅F₄N₃
Molecular Weight:385.364
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

Chemical Property:

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Technology Process of N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

There total 6 articles about N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610612-17-3
tert-butyl 4-fluorobenzyl (3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)carbamate

: 1610610-51-9
N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-51-9
N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-51-9
N-(4-fluorobenzyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: water; sodium hydroxide / methanol; 1,4-dioxane / 3 h / 20 °C

3.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; diphenyl phosphoryl azide; water; sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 3.1: |Curtius Rearrangement;