N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

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Chemical Name:N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide
CAS No.:890052-06-9
Molecular Formula:C₂₅H₃₁ClN₆O₃Si
Molecular Weight:527.098
Hs Code.:

Synonyms:N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

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Chemical Property of N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

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Technology Process of N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

There total 1 articles about N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 890051-96-4
N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenylene-1,4-diamine

: 43200-83-5
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid

: 890052-06-9
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

Guidance literature:: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenylene-1,4-diamine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃;

Reference yield: 82.0%

: 890052-06-9
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

: 506-68-3
bromocyane

: 890052-07-0
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(cyano)amino]phenyl}-N-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 40 ℃; for 12h;

Reference yield: 63.0%

: 890052-06-9
N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide

: 1096601-39-6
N-(5-chloropyridin-2-yl)-N'-{4-[(2-hydroxyethyl)amino]phenyl}-pyrazine-2,3-dicarboxamide

Guidance literature:: N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With water; In dichloromethane;