43200-83-5

Basic information

• Product Name: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid
• Synonyms: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid
• CAS NO: 43200-83-5
• Molecular Weight: 278.655
• Mol File: 43200-83-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 206-208 °C
• Boiling Point: 428.5±45.0 °C(Predicted)
• Density: 1.615±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid(43200-83-5)
• EPA Substance Registry System: 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid(43200-83-5)

Safety Data

• Hazardous Substances Data: 43200-83-5(Hazardous Substances Data)

Usage

Uses

3-[[(5-Chloro-2-pyridinyl)amino]carbonyl]-2-pyrazinecarboxylic acid is an impurity of Zopiclone (Z700500, a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 

Downstream Products

• 138729-47-2 eszopiclone 
• 43200-80-2 zopiclon 
• 43200-81-3 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 144025-93-4 eszopiclone dibenzoyl-D-tartrate 
• 144025-94-5 (R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt 
• 43200-82-4 6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine 
• 890052-06-9 N-{4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-N'-(5-chloropyridin-2-yl)pyrazine-2,3-dicarboxamide 

Relevant articles and documents

Process for the preparation of eszopiclone

The invention relates to a process for making of 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo-[3,4-b] pyrazin-5-yl-4-methyl piperazine-1-carboxylate, also known as zopiclone. The invention further describes an effective method for resolving of zopiclone into its enantiomers (eszopiclone and (R)-zopiclone) and also provides a method of recycling of (R)-zopiclone.

CYCLIC IMINOCARBAMATES AND USE THEREOF

The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z and n have the meaning cited in the description, to a method for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses, and to the use thereof in the production of medicaments for treating and/or for the prophylaxis of diseases, in particular of thromboembolic diseases.