methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Base Information

Chemical Name:methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate
CAS No.:1254207-51-6
Molecular Formula:C₁₄H₁₀ClF₃N₂O₄S
Molecular Weight:394.759
Hs Code.:

Synonyms:methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

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Technology Process of methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

There total 1 articles about methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 63555-50-0
methyl 3-chlorosulfonylbenzoate

: 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine

: 1254207-51-6
methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Guidance literature:: 2-amino-3-chloro-5-(trifluoromethyl)pyridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃;

methyl 3-chlorosulfonylbenzoate; In tetrahydrofuran; mineral oil; at 0 - 25 ℃;

Reference yield:

: 1254207-51-6
methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

: 1254207-52-7
methyl 3-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2014.10.074

Reference yield:

: 1254207-51-6
methyl 3-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoate

: 1254205-89-4
3-(N-benzyl-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 80 °C

2: sodium hydroxide / tetrahydrofuran; water / 50 °C

With caesium carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.10.074