79456-26-1

Basic information

• Product Name: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine
• Synonyms: TIMTEC-BB SBB003584;LABOTEST-BB LT00012608;2-AMINO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;2,3,5-actf;3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINAMINE;3-Chloro-5-(trifluoromethyl)-2-pyridylamine;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-AMINE
• CAS NO: 79456-26-1
• Molecular Formula: C₆H₄ClF₃N₂
• Molecular Weight: 196.56
• EINECS: 401-670-0
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Amines;Pyridines;Pyridine;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Fluorine series;amine| alkyl chloride
• Mol File: 79456-26-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 86-90 °C(lit.)
• Boiling Point: 205°C
• Flash Point: 75.7 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.4650 (estimate)
• Vapor Pressure: 0.306mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 1.79±0.49(Predicted)
• Water Solubility: 622mg/L at 25℃
• CAS DataBase Reference: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)
• EPA Substance Registry System: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine(79456-26-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-52/53-36/37/38-20/21/22
• Safety Statements: 61-36/37/39-26-22
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 79456-26-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

2-?Amino-?3-?chloro-?5-?trifluoromethylpyrid?ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.

InChI:InChI=1/C6H4ClF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)

Synthetic route

2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With ammonia In tetrahydrofuran at 35℃; under 1950.2 Torr; for 28h; Product distribution / selectivity; Autoclave; Inert atmosphere;	99.5%
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;	94%
With ammonia In tetrahydrofuran at 30℃; under 3750.38 - 6750.68 Torr; for 30h; Temperature; Pressure; Autoclave; Inert atmosphere;

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With ammonia In water at 80℃; under 13501.4 - 16501.7 Torr; for 9h; Autoclave;	90%
With ammonium hydroxide at 100℃; for 12h; Sealed tube;	90%
With ammonium hydroxide at 100 - 125℃; under 1520 Torr; for 29h;	82.9%
With ammonium hydroxide
With ammonia In tetrahydrofuran at 100℃; under 4500.45 - 12001.2 Torr; for 28h; Pressure; Temperature; Autoclave; Inert atmosphere;

5-bromo-3-chloropyridin-2-ylamine (38185-55-6) + potassium trifluoro(methyl)boranuide → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 55 - 105℃; for 6h; Temperature;	76%

2-amino-5-trifluoromethylpyridine (74784-70-6) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With hydrogenchloride; chlorine at 50 - 60℃;

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: 39 percent / aq. ammonia / 8 h / 180 °C 2: chlorine, conc.HCl / 50 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: 75 percent / aq. ammonia / 24 h / 135 °C 2: chlorine, conc.HCl / 50 - 60 °C View Scheme

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: 54.5 percent / antimony trifluoride / 0.17 h / Heating 2: 39 percent / aq. ammonia / 8 h / 180 °C 3: chlorine, conc.HCl / 50 - 60 °C View Scheme
Multi-step reaction with 3 steps 1: 54.5 percent / antimony trifluoride / 0.17 h / Heating 2: 75 percent / aq. ammonia / 24 h / 135 °C 3: chlorine, conc.HCl / 50 - 60 °C View Scheme

2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation 2: 82.9 percent / aq. ammonia / 29 h / 100 - 125 °C / 1520 Torr View Scheme
Multi-step reaction with 2 steps 1: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 2: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme

tert-butylhypochlorite (507-40-4) + 2-amino-5-trifluoromethylpyridine (74784-70-6) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With hydrogenchloride; acetic acid In toluene

ammonium hydroxide + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

3-trichloromethyl-pyridine (3099-50-1) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme
Multi-step reaction with 4 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: phosphorus pentachloride / 16 h / 210 °C / Autoclave 3: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 4: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme

5-chloro-3-trichloromethyl pyridine → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 16 h / 210 °C / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme

nicotinic acid (59-67-6) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 14 h / 210 °C / 1500.15 - 27752.8 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 64 h / 185 °C / 18751.9 - 30003 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme
Multi-step reaction with 3 steps 1: phosphorus pentachloride / 72 h / 185 °C / 18751.9 - 30003 Torr / Autoclave 2: hydrogen fluoride; iron(III) chloride; pyridine / 130 - 175 °C / Autoclave 3: ammonia / water / 9 h / 80 °C / 13501.4 - 16501.7 Torr / Autoclave View Scheme

3,6-dichloro-5-(trifluoromethyl)pyridin-2-amine (79456-29-4) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
With sulfuric acid; tetrabutylammomium bromide; dipotassium dicarbonochloridate; zinc at 30℃; for 7h; Temperature; Reagent/catalyst;	23.8 g

2-aminopyridine (504-29-0) → 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / tetrahydrofuran / -5 - 5 °C 2: N-chloro-succinimide / tetrahydrofuran / 15 h / 80 - 90 °C 3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 6 h / 55 - 105 °C View Scheme

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine (72537-17-8)

Conditions	Yield
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 20 deg C, 1 h;	99%
With pyridine; hydrogen fluoride; sodium nitrite 1.) 0 deg C, 30 min; 2.) 20 deg C, 1 h; Yield given. Multistep reaction;

2,4-dichloro-3,5-dinitro-benzotrifluoride (29091-09-6) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → fluazinam (79622-59-6)

Conditions	Yield
With potassium hydroxide In 2-methyltetrahydrofuran at 20℃; for 4h; Concentration; Temperature; Solvent;	98%
Stage #1: 2,4-dichloro-3,5-dinitro-benzotrifluoride; 2-amino-3-chloro-5-(trifluoromethyl)pyridine With methoxybenzene; potassium hydroxide at 55℃; for 6h; Stage #2: With hydrogenchloride at 85℃; pH=3.7; Temperature; Reagent/catalyst; pH-value;	98.5%
With edetate disodium; potassium hydroxide In acetonitrile at 0 - 5℃; for 3h; Reagent/catalyst; Temperature;	97.5%

2,4-di-tert-Butylphenol (96-76-4) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxy-3,5-(di-tert-butyl)benzene

Conditions	Yield
With potassium tert-butylate In ammonia at -78℃; for 2.5h; Irradiation;	98%

2-oxo-propionic acid (127-17-3) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (784144-05-4)

Conditions	Yield
With potassium phosphate; magnesium sulfate; acetic acid; bis(tri-t-butylphosphine)palladium(0) In N,N-dimethyl acetamide at 140℃; for 4h;	97%

3-pyridylboronic acid (1692-25-7) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 5-(trifluoromethyl)-[3,3']bipyridinyl-2-ylamine

Conditions	Yield
With potassium phosphate; XPhos; tris(dibenzylideneacetone)dipalladium (0) In butan-1-ol at 120℃; for 24h; Suzuki-Miyaura cross-coupling;	95%
With potassium phosphate; 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; tris(dibenzylideneacetone)dipalladium (0) In butan-1-ol at 120℃; for 24h; Suzuki-Miyaura reaction;	95%

2-formylthiophene-3-boronic acid (4347-31-3) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → C11H5F3N2S

Conditions	Yield
With sodium hydroxide In ethanol at 75℃; for 0.583333h; Suzuki-Miyaura Coupling; Microwave irradiation; Green chemistry;	95%

ethyl Bromopyruvate (70-23-5) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 8-chloro-6-(trifluoromethyl)imidazo[1,2,a]pyridine-2-carboxylic acid ethyl ester (353258-31-8)

Conditions	Yield
In ethanol at 20 - 80℃; for 12h;	93%
In ethanol at 80℃; for 48h;	86%
In ethanol at 80℃; for 48h;	86%

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + Benzoyl isothiocyanate (532-55-8) → N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamothioyl)benzamide

Conditions	Yield
In acetone at 56℃; for 48h;	93%
In tetrahydrofuran at 60℃; for 15h;	21%

cyclohexanone (108-94-1) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 4-chloro-2-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

Conditions	Yield
With iodine; oxygen In 1,1,2,2-tetrachloroethane at 160℃; for 24h; Green chemistry;	92%

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + β-naphthol (135-19-3) → 1-<3-(2-amino-4-trifluoromethylpyridyl)>-2-hydroxynaphthalene

Conditions	Yield
With potassium tert-butylate In ammonia at -78℃; for 4h; Irradiation;	90%

formaldehyd (50-00-0) + cyclopenta-1,3-diene (542-92-7) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → (3aR,10aR)-6-Chloro-8-trifluoromethyl-3a,10a-dihydro-3H,4H-cyclopenta[e]pyrido[1,2-a]pyrimidine

Conditions	Yield
With trifluoroacetic acid In acetonitrile for 1h; Heating;	90%

4-hydroxycoumarin-3-carboxaldehyde (51751-34-9) + tert-butylisonitrile (119072-55-8, 7188-38-7) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 3-(3-(tert-butylamino)-8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

Conditions	Yield
With acetic acid In methanol at 70℃; for 2h; Sealed tube;	90%

formaldehyd (50-00-0) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + 1-indene (95-13-6) → (6aS,11bR)-4-Chloro-2-trifluoromethyl-6,6a,7,11b-tetrahydro-5,11c-diaza-benzo[c]fluorene

Conditions	Yield
With trifluoroacetic acid In acetonitrile for 1h; Heating;	88%

4-hydroxycoumarin-3-carboxaldehyde (51751-34-9) + 1,1,3,3-tetramethylbutane isonitrile (14542-93-9) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 3-(8-chloro-6-(trifluoromethyl)-3-((2,4,4-trimethylpentan-2-yl)amino)imidazo[1,2-a]pyridin-2-yl)-4-hydroxy-2H-chromen-2-one

Conditions	Yield
With acetic acid In methanol at 70℃; for 2h; Sealed tube;	88%

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + 2-hydroxyethanethiol (60-24-2) → 2-<2-amino-5-(trifluoromethyl)pyridin-3-ylsulfanyl>ethanol

Conditions	Yield
With potassium tert-butylate for 1h; Irradiation;	85%

formaldehyd (50-00-0) + cyclohexa-1,3-diene (1165952-91-9) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → (6aR,10aR)-4-Chloro-2-trifluoromethyl-6a,7,8,10a-tetrahydro-6H-pyrido[1,2-a]quinazoline

Conditions	Yield
With trifluoroacetic acid In acetonitrile for 1h; Heating;	85%

2-methyl-benzyl alcohol (89-95-2) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol

Conditions	Yield
at 20℃; for 0.0666667h; microwave irradiation;	76%

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + bromoacetaldehyde (17157-48-1) → 8-Chloro-6-trifluoromethyl-imidazo[1,2-a]pyridine (178488-36-3)

Conditions	Yield
In ethanol Heating;	75%

ethyl 4,4,4-trifluoro-2-butynate (79424-03-6) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 9-chloro-4,7-bistrifluoromethylpyrido[1,2-a]pyrimidin-2-one

Conditions	Yield
In ethanol at 20℃; for 20h; Inert atmosphere;	75%

2-Picolinic acid (98-98-6) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)picolinamide (1210410-12-0)

Conditions	Yield
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 24h; Reflux;	74%

2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) + propargyl bromide (106-96-7) → 5-trifluoromethyl-3-chloro-2-amino-1-(2-propynyl)pyridinium bromide

Conditions	Yield
In isopropyl alcohol; toluene at 80℃; for 2h;	74%

styrene (292638-84-7) + formaldehyd (50-00-0) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 9-Chloro-4-phenyl-7-trifluoromethyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine

Conditions	Yield
With trifluoroacetic acid In acetonitrile for 1h; Heating;	70%

formaldehyd (50-00-0) + 1-Phenylcyclohexene (771-98-2) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → (6aS,10aS)-4-Chloro-10a-phenyl-2-trifluoromethyl-6a,7,8,9,10,10a-hexahydro-6H-pyrido[1,2-a]quinazoline

Conditions	Yield
With trifluoroacetic acid In acetonitrile for 1h; Heating;	70%

2,2-dihydroxy-1-phenyl-ethanone (1075-06-5) + dimedone (126-81-8) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 2-(8-chloro-2-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-3-hydroxy-5,5-dimethylcyclohex-2-enone

Conditions	Yield
With iodine In ethanol at 130℃; for 0.25h; Microwave irradiation;	68%

4-hydroxy[1]benzopyran-2-one (1076-38-6) + 2,2-dihydroxy-1-phenyl-ethanone (1075-06-5) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 3-(8-chloro-2-phenyl-6-(triuoromethyl)imidazo[1,2-a]pyridin-3-yl)-4-hydroxy-2H-chromen-2-one

Conditions	Yield
With iodine In ethanol at 130℃; for 0.25h; Microwave irradiation;	65%

hexafluoroacetone ethoxycarbonylimine (19846-30-1) + 2-amino-3-chloro-5-(trifluoromethyl)pyridine (79456-26-1) → 9-chloro-2,2,7-tris(trifluoromethyl)-2,3-dihydropyrido[1,2-a][1,3,5]triazin-4(3H)-one

Conditions	Yield
Stage #1: hexafluoroacetone ethoxycarbonylimine; 2-amino-3-chloro-5-(trifluoromethyl)pyridine In N,N-dimethyl-formamide Stage #2: With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 1h; Heating;	63%

Upstream product

• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 38185-55-6 5-bromo-3-chloropyridin-2-ylamine 
• 504-29-0 2-aminopyridine 
• 59-67-6 nicotinic acid 
• 3099-50-1 3-trichloromethyl-pyridine 
• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 
• 507-40-4 tert-butylhypochlorite 
• 74784-70-6 2-amino-5-trifluoromethylpyridine 
• 69045-83-6 2,3-dichloro-5-(trichloromethyl)pyridine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 79456-29-4 3,6-dichloro-5-(trifluoromethyl)pyridin-2-amine 

Downstream Products

• 193979-51-0 [8-Chloro-2-(4-chloro-phenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridin-3-yl]-acetic acid ethyl ester 
• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 
• 945971-04-0 3-methyl-5-(trifluoromethyl)pyridin-2-amine 
• 321430-46-0 N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamothioyl)benzamide 
• 1228372-85-7 2,5-dichloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)-1,2,4-oxadiazole-3-yl)phenol 
• 1228375-15-2 5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole 
• 1254305-62-8 C₁₅H₇Cl₃F₃N₃O₃S 
• 1254305-44-6 C₁₅H₈Cl₂F₃N₃O₃S 
• 1254305-43-5 C₁₆H₁₁ClF₃N₃O₃S 
• 1254305-99-1 C₁₆H₈ClF₆N₃O₃S 
• 1254305-94-6 C₁₆H₁₁ClF₃N₃O₄S 
• 353258-35-2 8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid 
• 1254304-28-3 C₁₆H₇Cl₂F₃N₄O₃S 
• 1254304-56-7 C₁₇H₁₀Cl₂F₃N₃O₅S 

Relevant articles and documents

Method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine

The invention discloses a method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. Specifically, starting from 2-aminopyridine, three chemical reactions of bromination, chlorination and coupling are involved, and two organic solvents are used in the whole process; and after the three-step reaction, recrystallization treatment is carried out to obtain the high-purity 2-amino-3-chloro-5-trifluoromethylpyridine. The method is mild in reaction condition and easy to control, and the obtained product is high in purity; reaction rawmaterials and organic solvents are easy to obtain and low in price, and a new way is provided for large-scale production.

Method for preparing 2-amino-3-chloro-5-trifluoromethylpyridine

The invention belongs to the technical field of pesticide intermediate synthesis, and relates to a method for preparing 2-amino-3-chloro-5-trifluoromethylpyridine. According to the method, 2, 3, 6-trichloro-5-trifluoromethylpyridine is used as a raw material, and amination and reduction reaction are performed to obtain the 2-amino-3-chloro-5-trifluoromethylpyridine. The byproduct 2, 3, 6-trichloro-5-trifluoromethylpyridine in a 2, 3-dichloro-5-trifluoromethylpyridine production process is used as the raw material to prepare the 2-amino-3-chloro-5-trifluoromethylpyridine, the synthesis cost ofthe 2-amino-3-chloro-5-trifluoromethylpyridine can be effectively reduced, and the purity of an obtained product meets the use requirements of industrial production.

Synthetic process of fluazinam

The invention discloses a synthetic process of fluazinam, and belongs to the technical field of pesticide chemical engineering. The process comprises the following steps: taking 2-halogen-3-chloro-5-trifluoromethyl pyridine and ammonia gas as raw materials to carry out an amination reaction in an ether solvent in a high-pressure kettle, carrying out desalination and deamination on the reaction liquid, then carrying out a condensation reaction with 2,4-dichloro-3,5-binitro-trifluorotoluene under an alkaline condition, and carrying out a conventional post-treatment method to obtain the fluazinam. According to the invention, in a continuous process of the two-step process, generation of side reactions of 2,4-dichloro-3,5-binitro-trifluorotoluene during the condensation reaction due to ammoniaresidues in an amine solution is avoided, so that unit consumption of the 2,4-dichloro-3,5-binitro-trifluorotoluene is reduced to a stoichiometric ratio, and product purification and yield are greatly improved. The product does not need to be purified, the purity can reach 99% or above, and the total separation yield of two steps can reach 97% or above.