C₁₀H₉ClO₂

Base Information

• Chemical Name: C₁₀H₉ClO₂
• CAS No.: 1194835-52-3
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Mol file: 1194835-52-3.mol

Synonyms:C₁₀H₉ClO₂

Chemical Property of C₁₀H₉ClO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₀H₉ClO₂

There total 2 articles about C₁₀H₉ClO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,5-dimethylphenyl)-2-oxoacetic acid → C10H9ClO2 (1194835-52-3)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

DOI:10.1039/b917958e DOI:10.1021/ja1027327

Reference yield:

(3,5-dimethylphenyl)-oxo-acetic acid ethyl ester (100117-62-2) → C10H9ClO2 (1194835-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 2 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;

DOI:10.1021/ol403480v

Reference yield:

C10H9ClO2 (1194835-52-3) + 2-bromo-N-methylaniline (6832-87-7) → N-(2-bromophenyl)-2-(3,5-dimethylphenyl)-N-methyl-2-oxoacetamide (1206913-03-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/b917958e

upstream raw materials:

(3,5-dimethylphenyl)-oxo-acetic acid ethyl ester

Downstream raw materials:

2-(3,5-dimethylphenyl)-N-methyl-2-oxo-N-phenylacetamide

N-(2-bromophenyl)-2-(3,5-dimethylphenyl)-N-methyl-2-oxoacetamide

N-allyl-N-benzyl-2-(3,5-dimethylphenyl)-2-oxoacetamide

N-allyl-2-azido-N-benzyl-2-(3,5-dimethylphenyl)acetamide

Refernces

• 1、 Zhang, Line,Lee, Jian-Yuan,Yamazaki, Naomi,Chiba, Shunsuke. "Copper(II)-catalyzed synthesis of pyrazinones from α-Azido-N- allylamides under an oxygen atmosphere". supporting information; experimental part. p. 2167 - 2170. Retrieved 2011/10/18.
• 2、 Chiba, Shunsuke,Zhang, Line,Lee, Jian-Yuan. "Copper-catalyzed synthesis of azaspirocyclohexadienones from ∝-azido- N -arylamides under an oxygen atmosphere". supporting information; experimental part. p. 7266 - 7267. Retrieved 2010/08/05.