N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

Base Information

Chemical Name:N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine
CAS No.:1447969-80-3
Molecular Formula:C₂₇H₃₇N₅O₅SSi
Molecular Weight:571.773
Hs Code.:

N<sup>6</sup>-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

Synonyms:N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

Suppliers and Price of N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

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Technology Process of N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

There total 1 articles about N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 67-68-5,8070-53-9
dimethyl sulfoxide

: 148692-01-7
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine

: 1447969-80-3
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

Guidance literature:: With acetic anhydride; acetic acid; at 20 ℃; for 48h;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield: 85.9%

: 126802-51-5
potassium 2,2-dimethyl-2-(2-nitrophenyl)acetate

: 1447969-80-3
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

: 1447969-81-4
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine

Guidance literature:: With 18-crown-6 ether; bromine; trimethylsilylacetylene; In 1,2-dichloro-ethane; for 1h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield:

: 1447969-80-3
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl-2’-O-[(methylthio)methyl]adenosine

: 923291-09-2
N⁶-benzoyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; trimethylsilylacetylene; 18-crown-6 ether / 1,2-dichloro-ethane / 1 h / Cooling with ice; Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / Inert atmosphere

With 18-crown-6 ether; bromine; triethylamine tris(hydrogen fluoride); trimethylsilylacetylene; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2013.06.001