5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole

Base Information

• Chemical Name: 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole
• CAS No.: 107311-59-1
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 107311-59-1.mol

Synonyms:5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole

Chemical Property of 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole

There total 3 articles about 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

5-<5-(2,6-dimethyl-4-iodophenoxy)pentyl>-3-methylisoxazole (107311-58-0) + 2-(trimethylstannyl)furan (51583-40-5) → 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole (107311-59-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jm00167a006

Reference yield:

4-iodo-2,6-dimethylphenol (10570-67-9) → 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole (107311-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / dimethylformamide

2: 54 percent / PdCl₂(PPh₃)2 / tetrahydrofuran / 5 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a006

Reference yield:

5-(5-bromopentyl)-3-methylisoxazole (98033-85-3) → 5-{5-[4-(2-furanyl)-2,6-dimethylphenoxy]pentyl}-3-methylisoxazole (107311-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / dimethylformamide

2: 54 percent / PdCl₂(PPh₃)2 / tetrahydrofuran / 5 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a006

upstream raw materials:

5-<5-(2,6-dimethyl-4-iodophenoxy)pentyl>-3-methylisoxazole

2-(trimethylstannyl)furan

4-iodo-2,6-dimethylphenol

5-(5-bromopentyl)-3-methylisoxazole