4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether

Base Information

• Chemical Name: 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether
• CAS No.: 728006-45-9
• Molecular Formula: C₁₉H₂₃ClO₂
• Molecular Weight: 318.843
• Mol file: 728006-45-9.mol

Synonyms:4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether

Chemical Property of 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether

There total 6 articles about 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

[2-(benzyloxy)-5-(tert-butyl)-1,3-phenylene]dimethanol (728006-44-8) → 4-tert-butyl-2,6-di(chloromethyl)phenyl benzyl ether + 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether (728006-45-9)

Guidance literature:

With pyridine; thionyl chloride; In benzene; for 16h; Heating;

DOI:10.1002/jhet.5570420626

Reference yield:

4-tert-butyl-2,5-bis(hydroxymethyl)phenol (2203-14-7) → 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether (728006-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / K₂CO₃ / ethanol / 18 h / Heating

2: 50 percent / pyridine; thionyl chloride / benzene / 16 h / Heating

With pyridine; thionyl chloride; potassium carbonate; In ethanol; benzene;

DOI:10.1002/jhet.5570420626

Reference yield:

para-tert-butylphenol (98-54-4) → 4-tert-butyl-2-hydroxymethyl-6-chloromethyl phenyl benzyl ether (728006-45-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / aq. NaOH / 30 - 40 °C

2: 70 percent / K₂CO₃ / ethanol / 18 h / Heating

3: 50 percent / pyridine; thionyl chloride / benzene / 16 h / Heating

With pyridine; sodium hydroxide; thionyl chloride; potassium carbonate; In ethanol; benzene;

DOI:10.1002/jhet.5570420626

upstream raw materials:

[2-(benzyloxy)-5-(tert-butyl)-1,3-phenylene]dimethanol

para-tert-butylphenol

4-tert-butyl-2,5-bis(hydroxymethyl)phenol

benzyl chloride

Downstream raw materials:

{2-benzyloxy-3-[10-(2-benzyloxy-5-tert-butyl-3-hydroxymethyl-benzyl)-1,7-dioxa-4,10-diaza-cyclododec-4-ylmethyl]-5-tert-butyl-phenyl}-methanol

{2-benzyloxy-3-[13-(2-benzyloxy-5-tert-butyl-3-hydroxymethyl-benzyl)-1,4,10-trioxa-7,13-diaza-cyclopentadec-7-ylmethyl]-5-tert-butyl-phenyl}-methanol

C₃₄H₅₄N₂O₇

C₃₂H₅₀N₂O₆