4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid

Base Information

• Chemical Name: 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid
• CAS No.: 871332-19-3
• Molecular Formula: C₂₂H₂₅N₇O₂
• Molecular Weight: 419.486
• Mol file: 871332-19-3.mol

Synonyms:4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid

Chemical Property of 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid

There total 2 articles about 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-amino-4-(4-phenylpiperazin-1-yl)-6-(1-bromomethyl)-1,3,5-triazine (871332-12-6) + N-methyl-p-aminobenzoic acid (10541-83-0,937737-33-2) → 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid (871332-19-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

N-carbamimidoyl-4-phenylpiperazine-1-carboximidic acid amide (786578-60-7) → 4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid (871332-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / methanol / 2.5 h / 20 °C

2: 97 percent / dimethylformamide / 12 h / 20 °C

In methanol; N,N-dimethyl-formamide;

Reference yield: 27.0%

4-({[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino)benzoic acid (871332-19-3) + methionine methyl ester hydrochloride (16118-36-8) → methyl {4-[{[2-amino-4-(4-phenylpiperazin-1-yl)-1,3,5-triazin-6-yl]methyl}methylamino]benzoyl}methioninate

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

2-amino-4-(4-phenylpiperazin-1-yl)-6-(1-bromomethyl)-1,3,5-triazine

N-methyl-p-aminobenzoic acid

N-carbamimidoyl-4-phenylpiperazine-1-carboximidic acid amide