6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

Base Information

Chemical Name:6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile
CAS No.:1600565-78-3
Molecular Formula:C₂₈H₁₈ClN₅O
Molecular Weight:475.937
Hs Code.:

Synonyms:6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

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Chemical Property of 6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

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Technology Process of 6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

There total 11 articles about 6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600565-48-7
(4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol

: 1600565-78-3
6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 22h; Sealed tube; Inert atmosphere;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-78-3
6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran / 1.67 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 22 h / 120 °C / Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; lithium hexamethyldisilazane; zinc; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water;

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 1600565-78-3
6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1.67 h / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 22 h / 120 °C / Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; ethylmagnesium bromide; zinc; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide;