1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-phenyl-, hydrobrom ide

Base Information

• Chemical Name: 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-phenyl-, hydrobrom ide
• CAS No.: 90955-43-4
• Molecular Formula: C16H17BrClNO
• Molecular Weight: 0
• Mol file: 90955-43-4.mol

Synonyms:8-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide;10-chloro-6-phenyl-4-azabicyclo[5.4.0]undeca-7,9,11-trien-9-ol hydrobromide;7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol;

Chemical Property of 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-phenyl-, hydrobrom ide

Chemical Property:

• Vapor Pressure: 7.01E-08mmHg at 25°C
• Boiling Point: 426.6°C at 760 mmHg
• Flash Point: 211.8°C
• PSA: 32.26000
• LogP: 4.61010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-phenyl-, hydrobrom ide

There total 4 articles about 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-phenyl-, hydrobrom ide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (73445-60-0) → 7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (90955-43-4)

Guidance literature:

With boron tribromide; In hexane; dichloromethane; 1.) -70 deg C, 1 h, 2.) RT, 2 h;

DOI:10.1021/jm00079a008

Reference yield:

3-chloro-4-methoxyphenethylamine (7569-87-1) → 7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (90955-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / acetonitrile / 16 h / Heating

2: 65 percent / PPA / 0.5 h / 100 °C

3: 40 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h

With boron tribromide; In hexane; dichloromethane; acetonitrile;

DOI:10.1021/jm00079a008

Reference yield:

2-amino>-1-phenylethanol (73445-59-7) → 7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (90955-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / PPA / 0.5 h / 100 °C

2: 40 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h

With boron tribromide; In hexane; dichloromethane;

DOI:10.1021/jm00079a008

upstream raw materials:

(+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

3-chloro-4-methoxyphenethylamine

2-amino>-1-phenylethanol

2-(3-chloro-4-methoxyphenyl)acetonitrile