(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

Base Information

Chemical Name:(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide
CAS No.:1082827-30-2
Molecular Formula:C₂₀H₂₉ClFNO₃Si
Molecular Weight:413.992
Hs Code.:

Synonyms:(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

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Chemical Property of (3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

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Technology Process of (3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

There total 4 articles about (3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₄O₄Si

: 72235-53-1
3,4-difluorobenzylamine

: 1082827-30-2
(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: C₂₀H₃₀O₄Si

: 1082827-30-2
(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

2: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With N-ethylmorpholine;; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1082827-30-2
(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 0.67 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

3: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With N-ethylmorpholine;; 2,6-dimethylpyridine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane;