N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

Base Information

Chemical Name:N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide
CAS No.:1082826-41-2
Molecular Formula:C₂₀H₂₀ClFN₄O
Molecular Weight:386.856
Hs Code.:

Synonyms:N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

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Chemical Property of N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

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Technology Process of N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

There total 5 articles about N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6978-97-8
3-(hydrazinylmethyl)pyridine dihydrochloride

: 1082827-30-2
(3Z)-3-acetyl-N-[(2-chloro-4-fluorophenyl)methyl]-4-{[(1,1-dimethylethyl)-(dimethyl)silyl]oxy}-3-pentenamide

: 1082826-41-2
N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

Guidance literature:: With sodium acetate; In ethanol; at 110 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: C₁₅H₁₉N₃O₂

: 15205-11-5
2-chloro-4-fluorobenzylamine

: 1082826-41-2
N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

Guidance literature:: C₁₅H₁₉N₃O₂; With water; lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 2h;

2-chloro-4-fluorobenzylamine; With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2010.03.096

Reference yield:

: C₂₀H₃₀O₄Si

: 1082826-41-2
N-[(2-chloro-4-fluorophenyl)methyl]-2-[3,5-dimethyl-1-(3-pyridinylmethyl)-1H-pyrazol-4-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

2: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: sodium acetate / ethanol / 0.75 h / 110 °C / Microwave irradiation

With N-ethylmorpholine;; hydrogen; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In ethanol; dichloromethane;