4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Base Information

Chemical Name:4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide
CAS No.:1616930-17-6
Molecular Formula:C₂₀H₁₆F₂N₆O₂
Molecular Weight:410.383
Hs Code.:

Synonyms:4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of 4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

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Technology Process of 4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

There total 9 articles about 4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: C₁₅H₁₃ClN₄O₂

: 1616930-17-6
4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

Reference yield: 24.0%

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 1616930-86-9
C₁₅H₁₄N₄O₃

: 1616930-17-6
4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: C₁₅H₁₄N₄O₃; With thionyl chloride; at 75 ℃; for 0.5h;

3,5-difluoropyridin-4-ylamine; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 20 ℃; for 1.5h;

Reference yield:

: 156001-51-3
3-Bromo-6-methyl-benzonitrile

: 1616930-17-6
4-amino-N-(3,5-difluoro-pyridin-4-yl)-1-methyl-5-(2-methyl-5-oxazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium / diethyl ether / 2 h / 20 °C

1.2: 4 h / Reflux

2.1: ethanol; sodium / diethyl ether / 20 h / 20 °C

3.1: dinitrogen trioxide / ethanol / 1 h / 20 °C

4.1: hydrogenchloride / water; ethanol / 1 h / 20 °C

4.2: 4 h / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 2 h / 90 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 1 h / Reflux

7.1: thionyl chloride / 0.5 h / 75 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; dinitrogen trioxide; ethanol; water; sodium; magnesium; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; acetonitrile; 5.1: |Stille Cross Coupling;